Science
Ecological erosion and expanding extinction risk of sharks and rays | Science (Fr, 06 Dez 2024)The true state of ocean biodiversity is difficult to assess, and there are few global indicators to track the primary threat of overfishing. We calculated a 50-year Red List Index of extinction risk and ecological function for 1199 sharks and rays and ...
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Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs | Science (Fri, 06 Dec 2024)
Immune homeostasis requires a balance of inflammatory and suppressive activities. To design cells potentially useful for local immune suppression, we engineered conventional CD4+ T cells with synthetic Notch (synNotch) receptors driving antigen-triggered ...
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Programming tissue-sensing T cells that deliver therapies to the brain | Science (Fri, 06 Dec 2024)
To engineer cells that can specifically target the central nervous system (CNS), we identified extracellular CNS-specific antigens, including components of the CNS extracellular matrix and surface molecules expressed on neurons or glial cells. Synthetic ...
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Imperfect wound healing sets the stage for chronic diseases | Science (Fri, 06 Dec 2024)
Although the age of the genome gave us much insight about how our organs fail with disease, it also suggested that diseases do not arise from mutations alone; rather, they develop as we age. In this Review, we examine how wound healing might act to ...
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News at a glance: Orange cats, COVID-19 origin probe, and a collapse of plastic treaty talks (Thu, 05 Dec 2024)
The latest in science and policy
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Latin American journals are open-access pioneers. Now, they need an audience (Thu, 05 Dec 2024)
SciElo, other platforms work to help journals reach readers around the world
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A microRNA is the effector gene of a classic evolutionary hotspot locus | Science (Thu, 05 Dec 2024)
In Lepidoptera (butterflies and moths), the genomic region around the gene cortex is a “hotspot” locus, repeatedly implicated in generating intraspecific melanic wing color polymorphisms across 100 million years of evolution. However, the identity of the ...
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A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors | Science (Thu, 05 Dec 2024)
In 2024, several human infections with highly pathogenic clade 2.3.4.4b bovine influenza H5N1 viruses in the United States raised concerns about their capability for bovine-to-human or even human-to-human transmission. In this study, analysis of the ...
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Climate change extinctions | Science (Thu, 05 Dec 2024)
Climate change is expected to cause irreversible changes to biodiversity, but predicting those risks remains uncertain. I synthesized 485 studies and more than 5 million projections to produce a quantitative global assessment of climate change ...
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A conserved bacterial genetic basis for commensal-host specificity | Science (Thu, 05 Dec 2024)
Animals selectively acquire specific symbiotic gut bacteria from their environments that aid host fitness. To colonize, a symbiont must locate its niche and sustain growth within the gut. Adhesins are bacterial cell surface proteins that facilitate ...
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Room-temperature exceptional plasticity in defective Bi2Te3-based bulk thermoelectric crystals | Science (Thu, 05 Dec 2024)
The recently discovered metal-like room-temperature plasticity in inorganic semiconductors reshapes our knowledge of the physical properties of materials, giving birth to a series of new-concept functional materials. However, current room-temperature ...
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In Other Journals | Science (Thu, 05 Dec 2024)
Editors’ selections from the current scientific literature
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In Science Journals | Science (Thu, 05 Dec 2024)
Highlights from the Science family of journals
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EU needs groundwater ecosystems guidelines | Science (Thu, 05 Dec 2024)
Negotiations are underway on the new European Union (EU) Water Directive (1), which will regulate the protection and sustainable use of Europe’s water resources. However, the proposal foregoes environmental quality standards specifically tailored to sensitive groundwater species and fails to require biomonitoring for groundwater ecosystems. Despite repeated calls for consideration (2, 3) since the first Water Framework Directive in 2000 (4), groundwater ecosystems are at risk of being overlooked yet again.
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Extending prosperity to Mexican seas | Science (Thu, 05 Dec 2024)
HomeScienceVol. 386, No. 6726Extending prosperity to Mexican seasBack To Vol. 386, No. 6726 Full accessLetter Share on Extending prosperity to Mexican seasOctavio Aburto-Oropeza [email protected], Catalina López-Sagástegui, [...] , Alejandro Robles, and Exequiel Ezcurra+1 authors fewerAuthors Info & AffiliationsScience5 Dec 2024Vol 386, Issue 6726pp. 1102-1103DOI: 10.1126/science.ads5826 PREVIOUS…
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Scopes monkey trial, in context | Science (Thu, 05 Dec 2024)
A writer reexamines the 20th-century showdown between science and religion
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On the origins of organisms | Science (Thu, 05 Dec 2024)
The heterotrophic theory of the origin of life turns 100
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Act on a mandate to protect research subjects’ privacy | Science (Thu, 05 Dec 2024)
Congress called for the protection of data from legal process
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Synthetic gene circuits drive disease-fighting T cells | Science (Thu, 05 Dec 2024)
Immune cells can be programmed to deliver targeted therapies in models of brain and inflammatory disease
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Continuous monitoring with a shake | Science (Thu, 05 Dec 2024)
Oscillating signals rapidly reset a sensor for real-time protein detection in the body
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Home sweet home | Science (Thu, 05 Dec 2024)
Sugar-binding adhesins enable bacteria to persist in specific host niches
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How the brain hatches an escape | Science (Thu, 05 Dec 2024)
A neuroendocrine circuit controls when fish larvae are ready to hatch
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Science and America’s challenge | Science (Thu, 05 Dec 2024)
Today, more than at any time since World War II, the United States is being challenged scientifically on the global stage. Unfortunately, the nation is not meeting the moment. With a new administration in the wings, the country must begin to monitor ...
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Could melting ice wake up Antarctica’s volcanoes? (Tue, 03 Dec 2024)
Researchers probe immediate and long-term threats at two of continent’s biggest magmatic tinderboxes
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‘Brutal’ math test stumps AI but not human experts (Tue, 03 Dec 2024)
Benchmark shows humans can still top machines—but for how much longer?
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Controversial study redraws classical picture of the neuron (Mon, 02 Dec 2024)
Fine-grained imaging of mouse brain cells suggests “pearling” of axons that researchers think may help with signaling
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War-torn Ukraine has become a breeding ground for lethal drug-resistant bacteria (Wed, 27 Nov 2024)
Urgent action underway to prevent dangerous microbes from spreading beyond country's borders
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Controversial health economist is Trump’s pick to head NIH (Wed, 27 Nov 2024)
Researchers have mixed views on nomination of Jay Bhattacharya to head biomedical research agency
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Mixed reactions greet Trump’s pick of longtime FDA critic to head agency (Tue, 26 Nov 2024)
Surgeon Martin Makary, who opposed COVID-19 vaccine mandates, may have to choose between public health and politics
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Dissecting the hydrogen bond network of water: Charge transfer and nuclear quantum effects | Science (Thu, 24 Oct 2024)
The molecular structure of water is dynamic, with intermolecular hydrogen (H) bond interactions being modified by both electronic charge transfer and nuclear quantum effects (NQEs). Electronic charge transfer and NQEs potentially change under acidic or ...
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