Science

A cellulose synthase–like protein governs the biosynthesis of Solanum alkaloids | Science (Fr, 20 Dez 2024)
Decades of research on the infamous antinutritional steroidal glycoalkaloids (SGAs) in Solanaceae plants have provided deep insights into their metabolism and roles. However, engineering SGAs in heterologous hosts has remained a challenge. We discovered ...
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Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice | Science (Fri, 20 Dec 2024)
Deciphering the complex interplay between neuronal activity and mitochondrial function is pivotal in understanding brain aging, a multifaceted process marked by declines in synaptic function and mitochondrial performance. Here, we identified an age-...
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Quantifying the global biodiversity of Proterozoic eukaryotes | Science (Fri, 20 Dec 2024)
The global diversity of Proterozoic eukaryote fossils is poorly quantified despite its fundamental importance to the understanding of macroevolutionary patterns and dynamics on the early Earth. Here we report a new construction of fossil eukaryote ...
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Cellular RNA interacts with MAVS to promote antiviral signaling | Science (Fri, 20 Dec 2024)
Antiviral signaling downstream of RIG-I–like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein complex function can be modulated by RNA molecules that ...
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News at a glance: Mars rover’s big ascent, Europa’s ice sheet, and House committee chairs (Thu, 19 Dec 2024)
The latest in science and policy
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Experiments outside the lab come with new responsibilities | Science (Thu, 19 Dec 2024)
St. Ives is an idyllic seaside town on the southwest tip of England. It is a magnet for holidaymakers and artists. In early 2023, its residents were surprised to find that their beloved bay had become the location for an experiment. A technology start-up ...
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The struggles and joys of being an Indigenous researcher in the academy | Science (Thu, 19 Dec 2024)
In November I took part in two very different gatherings—one in Canada, the other in Aotearoa New Zealand—which highlight both the ongoing struggles and joys of being an Indigenous researcher in the academy.
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Quantum collective motion of macroscopic mechanical oscillators | Science (Thu, 19 Dec 2024)
Collective phenomena arise from interactions within complex systems, leading to behaviors absent in individual components. Observing quantum collective phenomena with macroscopic mechanical oscillators has been impeded by the stringent requirement that ...
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Hydrodynamic moiré superlattice | Science (Thu, 19 Dec 2024)
The structural periodicity in photonic crystals guarantees the crystal’s effective energy band structure, which is the fundamental cornerstone of topological and moiré physics. However, the shear modulus in most fluids is close to zero, which makes it ...
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Hydrogenotrophic methanogens overwrite isotope signals of subsurface methane | Science (Thu, 19 Dec 2024)
Methane, a greenhouse gas and energy source, is commonly studied using stable isotope signals as proxies for its formation processes. In subsurface environments, methane often exhibits equilibrium isotopic signals, but the equilibration process has never ...
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In Other Journals | Science (Thu, 19 Dec 2024)
Editors’ selections from the current scientific literature
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In Science Journals | Science (Thu, 19 Dec 2024)
Highlights from the Science family of journals
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Red tape strangles viral surveillance programs | Science (Thu, 19 Dec 2024)
Viral surveillance is crucial to detecting isolated disease outbreaks and preventing them from growing into epidemics or pandemics. Gaps in disease surveillance contributed to the 2020 COVID pandemic (1) and the 2014 Ebola outbreak (2). Because viruses know no borders, US viral surveillance relies on sending reagents, which are used to detect the presence of specific viruses, to countries where outbreaks are likely to emerge. However, changes in US export controls have hindered these efforts.
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FDA should consider drug-therapy regimens | Science (Thu, 19 Dec 2024)
In his In Depth story “What’s next for psychedelics after MDMA rejection?” (16 August, p. 702), K. Kupferschmidt describes how the US Food & Drug Administration (FDA) turned down the application of a combination of 3,4-methylenedioxymethamphetamine (MDMA), also known as ecstasy, and psychotherapy for posttraumatic stress disorder, in part because the regimen involves both a drug and psychotherapy. FDA decision-makers determined that they can regulate drugs but not psychotherapies. Kupferschmidt warns that as a result, ongoing clinical trials will likely steer away from drug-psychotherapy combinations, to the detriment of patients.
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Conflict drives mpox epidemic in eastern DRC | Science (Thu, 19 Dec 2024)
HomeScienceVol. 386, No. 6728Conflict drives mpox epidemic in eastern DRCBack To Vol. 386, No. 6728 Full accessLetter Share on Conflict drives mpox epidemic in eastern DRCMisaki Wayengera [email protected]Authors Info & AffiliationsScience19 Dec 2024Vol 386, Issue 6728p. 1356DOI: 10.1126/science.adt3171 PREVIOUS ARTICLEBecoming Roger PenrosePreviousNEXT ARTICLEFDA should consider drug-therapy reg…
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Becoming Roger Penrose | Science (Thu, 19 Dec 2024)
A journalist paints a complex and rewarding portrait of the mathematical physicist
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Return of the phage | Science (Thu, 19 Dec 2024)
The pros and cons of alternative antimicrobial therapies are worth considering in an age of antibiotic resistance
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Aged neurons don’t register energy need | Science (Thu, 19 Dec 2024)
Neuronal activity and mitochondrial gene expression become decoupled in aged mice
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Thermal radiation with a twist | Science (Thu, 19 Dec 2024)
Carbon nanotube filaments with a twisted geometry emit spinning heat waves at high temperatures
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Platform influencers—host RNA control of antiviral immunity | Science (Thu, 19 Dec 2024)
Cellular RNAs directly regulate the activity of an antiviral immune signaling complex
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A common immune response node in diverse plants | Science (Thu, 19 Dec 2024)
Small molecules activate a defense mechanism shared by all flowering plants
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Tolerance on trial | Science (Thu, 19 Dec 2024)
Next year will mark the 100th anniversary of the Scopes trial, a 1925 court case in the US state of Tennessee on the teaching of evolution in public schools. John Scopes was tried for violating the Butler Act, a state rule that declared unlawful any ...
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Shoddy commentaries—a quick and dirty route to higher impact numbers—are on the rise (Tue, 17 Dec 2024)
AI-generated content floods literature with poor-quality publications, casts doubt on metrics, Science and Retraction Watch investigation finds
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Could psychedelic drugs improve the mental health of autistic people? (Tue, 17 Dec 2024)
A brace of new studies probes benefits and risks for an understudied group
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Possible ban on Chinese-made drones dismays U.S. scientists (Mon, 16 Dec 2024)
Switching to costlier, less capable drones could impede research on whales, forests, and more
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U.S. climate scientists gird for a second Trump administration (Fri, 13 Dec 2024)
Trump allies have vowed to squash research and fire adversaries
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Confronting risks of mirror life | Science (Thu, 12 Dec 2024)
Broad discussion is needed to chart a path forward
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Can Congo contain its exploding mpox epidemic—and curtail its international spread? (Mon, 09 Dec 2024)
Efforts to control the virus are hampered by vaccine shortages, logistical problems, and bureaucracy
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Mysterious radio pulses traced to dance of stellar dwarfs (Wed, 04 Dec 2024)
Languorous cosmic beats could be generated by magnetic forces between orbiting stars
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A scaffold protein manages the biosynthesis of steroidal defense metabolites in plants | Science (Thu, 17 Oct 2024)
Solanaceae plants produce two major classes of valuable sterol-derived natural products—steroidal glycoalkaloids and steroidal saponins—from a common cholesterol precursor. Attempts to heterologously produce these molecules have consistently failed, ...
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