Science
Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells | Science (Fr, 26 Apr 2024)Chemical modulation of proteins enables a mechanistic understanding of biology and represents the foundation of most therapeutics. However, despite decades of research, 80% of the human proteome lacks functional ligands. Chemical proteomics has advanced ...
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Genomic factors shape carbon and nitrogen metabolic niche breadth across Saccharomycotina yeasts | Science (Fri, 26 Apr 2024)
Organisms exhibit extensive variation in ecological niche breadth, from very narrow (specialists) to very broad (generalists). Two general paradigms have been proposed to explain this variation: (i) trade-offs between performance efficiency and breadth ...
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Sequence basis of transcription initiation in the human genome | Science (Fri, 26 Apr 2024)
Transcription initiation is a process that is essential to ensuring the proper function of any gene, yet we still lack a unified understanding of sequence patterns and rules that explain most transcription start sites in the human genome. By predicting ...
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Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules | Science (Fri, 26 Apr 2024)
Tubulin, one of the most abundant cytoskeletal building blocks, has numerous isotypes in metazoans encoded by different conserved genes. Whether these distinct isotypes form cell type– and context-specific microtubule structures is poorly understood. ...
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A gene mutation turned these fish into intrepid explorers (Thu, 25 Apr 2024)
That behavioral change could explain the remarkable diversity of cichlid fish in Africa’s Lake Tanganyika
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News at a glance: Plants’ tree of life, conserving U.S. federal lands, and entertaining invertebrate sentience (Thu, 25 Apr 2024)
The latest in science and policy
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Can science find ways to ease loneliness? (Thu, 25 Apr 2024)
The health risks of social isolation and loneliness are inspiring government action and a hunt for effective interventions
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War: not an unlikely topic for science lessons | Science (Thu, 25 Apr 2024)
As a seven-year-old child, I experienced war in Cyprus. Armed conflict has not been far from my conscience ever since. At a time when there are active conflicts in many parts of the world, war is unlikely to be far from many children’s minds globally ...
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Observation of a Chern insulator in crystalline ABCA-tetralayer graphene with spin-orbit coupling | Science (Thu, 25 Apr 2024)
Degeneracies in multilayer graphene, including spin, valley, and layer degrees of freedom, can be lifted by Coulomb interactions, resulting in rich broken-symmetry states. Here, we report a ferromagnetic state in charge-neutral ABCA-tetralayer graphene ...
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Nickel binding enables isolation and reactivity of previously inaccessible 7-aza-2,3-indolynes | Science (Thu, 25 Apr 2024)
N-Heteroaromatics are key elements of pharmaceuticals, agrochemicals, and materials. N-Heteroarynes provide a scaffold to build these essential molecules but are underused because five-membered N-heteroarynes have been largely inaccessible on account of ...
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In Other Journals | Science (Thu, 25 Apr 2024)
Editors’ selections from the current scientific literature
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In Science Journals | Science (Thu, 25 Apr 2024)
Highlights from the Science family of journals
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Map and protect seagrass for biodiversity | Science (Thu, 25 Apr 2024)
Seagrass meadows—marine ecosystems that support biodiversity and provide a range of other ecosystem services—are globally in decline (1). Many species use seagrass meadows as foraging grounds, spawning grounds, and shelter, including migratory species such as brant geese, the dugong, and the green turtle (2, 3). Conserving these valuable ecosystems will require comprehensive global maps of their locations (4) and a better understanding of the species that depend on them (3).
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Livestock intensification: No panacea for emissions | Science (Thu, 25 Apr 2024)
During the 28th annual meeting of the Conference of Parties to the UN Framework Convention on Climate Change (COP28) held in November and December 2023, the UN Food and Agriculture Organization (FAO) released a roadmap for transforming food systems. The plan aims to end world hunger without breaching the relatively safe 1.5°C global temperature rise threshold (1). The livestock industry is food systems’ biggest climate culprit, accounting for more than half of food systems emissions (2) and at least 16.5% of all anthropogenic greenhouse gas (GHG) emissions (2, 3). FAO’s roadmap calls for intensification of livestock production—i.e., keeping more livestock in less space—to cut GHG emissions. However, this recommendation conflicts with the findings in past FAO reports (4, 5) and will not solve the problem of livestock emissions.
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Dangers of disposable electronic devices | Science (Thu, 25 Apr 2024)
HomeScienceVol. 384, No. 6694Dangers of disposable electronic devicesBack To Vol. 384, No. 6694 Full accessLetter Share on Dangers of disposable electronic devicesLaura Young [email protected], Sue Dawson, [...] , David Lavallee, Mark Midownik, [...] , Imogen Napper, Richard Thompson, and Rebecca Wade+4 authors +2 authors fewerAuthors Info & AffiliationsScience25 Apr 2024Vol 384, Issue 6694p. 393…
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A future to look forward to | Science (Thu, 25 Apr 2024)
HomeScienceVol. 384, No. 6694A future to look forward toBack To Vol. 384, No. 6694 Full accessBooks et al.Podcast Share on A future to look forward toScience25 Apr 2024Vol 384, Issue 6694p. 392DOI: 10.1126/science.adp6426 PREVIOUS ARTICLEData, death, and what comes nextPreviousNEXT ARTICLEDangers of disposable electronic devicesNext ContentsInformation & AuthorsMetrics & CitationsView OptionsRe…
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Data, death, and what comes next | Science (Thu, 25 Apr 2024)
A scholar outlines how to respect the digital traces the dead leave behind
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Sustainable justice | Science (Thu, 25 Apr 2024)
The needs of marginalized groups must be central to sustainability goals, argues a sociologist
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Corporate emissions targets and the neglect of future innovators | Science (Thu, 25 Apr 2024)
Targets can distort competition in favor of incumbent firms
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Frans de Waal (1948–2024) | Science (Thu, 25 Apr 2024)
Primatologist who brought animals and humans “a little closer”
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Developing future nanomedicines | Science (Thu, 25 Apr 2024)
Quantitative analysis of biodistribution and clearance may improve nanoparticle development
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Microbes and vitamin D aid immunotherapy | Science (Thu, 25 Apr 2024)
Vitamin D modulates intestinal epithelial cell function to enhance antitumor microbes
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How DNA encodes the start of transcription | Science (Thu, 25 Apr 2024)
A deep-learning model reveals the rules that define transcription initiation
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A sound beginning of life starts before birth | Science (Thu, 25 Apr 2024)
Long-term impact from prenatal noise exposure in birds should raise general concern
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Science needs neurodiversity | Science (Thu, 25 Apr 2024)
All brains work differently. Individuals process information and engage with the world in ways that are influenced by a multitude of biological, cultural, and social factors. In the world of science, these differences are what spark innovation. This is ...
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China set to fetch first rocks from mysterious far side of the Moon (Wed, 24 Apr 2024)
Chang’e-6 to target the largest and oldest lunar impact crater
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U.S. government in hot seat for response to growing cow flu outbreak (Mon, 22 Apr 2024)
Veterinarians and researchers on the front lines say it has taken too long to share data on viral changes, spread, and milk safety
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Oldest ever ice offers glimpse of Earth before the ice ages (Mon, 22 Apr 2024)
Climate snapshots suggest carbon dioxide levels were surprisingly modest during ancient warm period
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Africa intensifies battle against mpox as ‘alarming’ outbreaks continue (Sat, 20 Apr 2024)
New variant identified in Congolese mining town renews worries about global spread
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Controversial wolf killing appears to help caribou, but concerns persist (Thu, 18 Apr 2024)
Some worry the findings will stall efforts to halt logging—the root cause of declining caribou populations
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